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Curr Opin Cell Biol. 2004 Jun;16(3):279-84.

The ever-increasing complexities of the exon junction complex.

Author information

1
Howard Hughes Medical Institute, Department of Biochemistry, MS009, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA.

Abstract

Over the past decade many studies have revealed a complex web of interconnections between the numerous steps required for eukaryotic gene expression. One set of interconnections link nuclear pre-mRNA splicing and the subsequent metabolism of the spliced mRNAs. It is now apparent that the means of connection is a set of proteins, collectively called the exon junction complex, which are deposited as a consequence of splicing upstream of mRNA exon-exon junctions.

PMID:
15145352
DOI:
10.1016/j.ceb.2004.03.012
[Indexed for MEDLINE]

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