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Biochem Biophys Res Commun. 2004 Jun 4;318(3):680-3.

Paraoxonase-1 inhibits oxidised LDL-induced MCP-1 production by endothelial cells.

Author information

1
Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK. bharti.mackness@cmmc.nhs.uk

Abstract

The upregulation of endothelial cell MCP-1 production by ox-LDL is a major initiating event in atherogenesis. HDL and PON1 retard the oxidation of LDL and therefore may retard endothelial cell MCP-1 production. The endothelial cell line EAhy926 was incubated with ox-LDL in the presence and absence of HDL and PON1 and the production of MCP-1 was measured by ELISA. Human HDL and PON1 significantly inhibited the in vitro oxidation of LDL and completely prevented the ox-LDL induced increase in MCP-1 production by endothelial cells. Ostrich HDL that does not contain PON1 was unable to prevent LDL-oxidation or the production of MCP-1 by endothelial cells. PON1 attenuates the ox-LDL induced MCP-1 production by endothelial cells. This is one, early, mechanism by which PON1 may be anti-atherogenic.

PMID:
15144891
DOI:
10.1016/j.bbrc.2004.04.056
[Indexed for MEDLINE]

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