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Clin Exp Allergy. 2004 May;34(5):757-60.

Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma.

Author information

1
Department of Pulmonary Diseases, University Hospital, Groningen, The Netherlands.

Abstract

BACKGROUND:

Asthma is a genetically complex disease characterized by respiratory symptoms, intermittent airway obstruction and airway hyper-responsiveness due to airway inflammation and remodelling. The ADAM33 gene is associated with asthma and airway hyper-responsiveness and is postulated as a gene for airway remodelling.

OBJECTIVE:

To investigate whether polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in patients with asthma.

METHODS:

In a cohort of 200 asthma patients followed over 20 years, eight single nucleotide polymorphisms of the ADAM33 gene were analysed to estimate their effect on annual FEV(1) decline.

RESULTS:

The rare allele of the S_2 polymorphism was significantly associated with excess decline in FEV(1) (P<0.05).

CONCLUSION:

These findings suggest that a variant in ADAM33 is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling.

PMID:
15144468
DOI:
10.1111/j.1365-2222.2004.1938.x
[Indexed for MEDLINE]

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