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Res Microbiol. 2004 Apr;155(3):129-35.

Omp85, an evolutionarily conserved bacterial protein involved in outer-membrane-protein assembly.

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  • 1Department of Molecular Microbiology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

Abstract

The insertion of proteins into membranes generally requires the assistance of membrane proteins. A protein, designated Omp85 in Neisseria meningitidis, was shown to be required for the assembly of bacterial outer-membrane proteins. The protein is essential for the viability of the bacteria and is ubiquitous among Gram-negative bacteria. Omp85 depletion results in the accumulation of aggregates of unfolded outer-membrane proteins, and we argue that Omp85 is directly involved in outer-membrane-protein assembly. Omp85 shows sequence similarity with Toc75 of the chloroplast protein-import machinery, suggesting a common evolutionary origin.

PMID:
15143770
DOI:
10.1016/j.resmic.2003.11.007
[PubMed - indexed for MEDLINE]
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