Format

Send to

Choose Destination
See comment in PubMed Commons below
Med Hypotheses. 2004;62(6):868-70.

Conditions of aging as manifestations of sympathetic bias unmasked by loss of parasympathetic function.

Author information

1
Department of Medicine, Stanford University, 470 University Avenue, Palo Alto, CA 94301, USA.

Abstract

We propose a unifying hypothesis that many clinical consequences of aging are pleiotropic manifestations of the loss of parasympathetic function that occurs during post-reproductive senescence. The loss of parasympathetic function unmasks the baseline sympathetic bias inherent in the end-organs, resulting in the familiar signs of aging including tachycardia, constipation, insomnia, erectile dysfunction, fluid retention, and systemic inflammation. These consequences in turn may contribute to many of the common diseases associated with aging including type-2 diabetes, Alzheimer's, atherosclerosis, and cancer. Maintenance and restoration of parasympathetic function may enable upstream control over the deleterious aspects of inherent end-organ adrenergic bias.

PMID:
15142638
DOI:
10.1016/j.mehy.2003.11.024
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center