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Immunity. 2004 May;20(5):517-27.

Pathogenic roles of B cells in human autoimmunity; insights from the clinic.

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Department of Immunology, One DNA Way, MS-34, South San Francisco, CA 94080 USA.


The pathogenic roles of B cells in human autoimmune diseases involve a multitude of mechanistic pathways and include the well-established contributions of autoantibodies and immune complexes that induce local inflammatory reactions and tissue destruction. Recent results using several novel B cell-directed therapies have provided new insights into additional roles of B cells in human autoimmunity. In this review, we will highlight some of these studies and discuss how clinical insights parallel murine models of normal immunity and autoimmunity.

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