Format

Send to

Choose Destination
See comment in PubMed Commons below
Arthritis Res Ther. 2004;6(3):120-8. Epub 2004 Apr 29.

Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells.

Author information

1
Division of Rheumatology, T-3219 Medical Center North, Vanderbilt University, Nashville, Tennessee, USA. nancy.olsen@vanderbilt.edu

Abstract

The relatively new technology of DNA microarrays offers the possibility to probe the human genome for clues to the pathogenesis and treatment of human disease. While early studies using this approach were largely in oncology, many new reports are emerging in other fields including infectious diseases and pharmacology, and applications in autoimmunity have been recently reported by our group and others. Some of these investigations have examined animal models of autoimmune disease, but a number of human studies have also been carried out. Of special interest are those that have used peripheral blood samples because, unlike tissue biopsies, these are readily available from all subjects. Using this approach, patterns of gene expression can be detected that distinguish patients with autoimmune conditions from normal subjects. Furthermore, the genes that are identified provide clues to possible pathogenetic mechanisms and are likely to be useful in developing tests to establish diagnostic categories and predict therapeutic responses.

PMID:
15142262
PMCID:
PMC416456
DOI:
10.1186/ar1190
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center