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Aliment Pharmacol Ther. 2004 May 15;19(10):1099-104.

Health-related quality of life in patients with cardiovascular disease--the effect of upper gastrointestinal symptom treatment.

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1
Department of Gastroenterology, Heart Center, University Medical Center St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands. l.vanrossum@mdl.umcn.nl

Abstract

BACKGROUND:

Upper gastrointestinal discomfort decreases the already impaired health status of patients with cardiovascular disease.

AIM:

To evaluate whether acid suppressive therapy improves health-related quality of life in patients who developed upper gastrointestinal symptoms after starting low-dose acetylsalicylic acid.

METHODS:

In a double-blind, placebo-controlled randomized trail, cardiac patients using low-dose (80 mg) acetylsalicylic acid with (n = 142) and without (n = 90) upper gastrointestinal symptoms were included. Patients with symptoms were treated with rabeprazole or placebo for 4 weeks. At baseline and 4 weeks information about gastrointestinal symptoms and health-related quality of life was assessed.

RESULTS:

The 73 patients assigned to rabeprazole when compared with 69 patients given placebo reported the same quality of life scores 4 weeks after randomization. The differences in quality of life scores between patients with and without symptoms at baseline remained after 4 weeks. Patients in whom treatment led to complete symptom relief or those who remained symptom-free reported significantly higher scores for Physical Component Summary (P < 0.01) and Mental Component Summary (P < 0.01), when compared to those with persistent symptoms or new onset symptoms.

CONCLUSION:

Proton-pump inhibitor therapy did not improve quality of life. Upper gastrointestinal symptom relief in itself considerably increased quality of life.

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