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Eur J Obstet Gynecol Reprod Biol. 2004 Jun 15;114(2):210-4.

p53 at codon 72 polymorphism, human papillomavirus infection and cervical lesions: a cross-sectional study from northeastern Italy.

Author information

1
Department of Public Medicine Sciences, U.C.O. Hygiene and Preventive Medicine, University of Trieste, I.R.C.C.S. Burlo Garofolo, Via dell'Istria 65/1, Trieste 34100, Italy. comar@burlo.trieste.it

Abstract

OBJECTIVE:

To test the hypothesis that p53 homozygous Arg/Arg genotype at codon 72 is a significant risk factor for the development of HPV induced cervical cancer.

STUDY DESIGN:

A cross-sectional survey on p53 allelotypes distribution in women with different grade of cervical lesions and with or without HPV infection, in comparison to the distribution on a control group of women cytologically normal and HPV negative.

RESULTS:

No statistically significant difference in the p53 polymorphism distribution was found in relation to the infection with HPV, the cytological pattern and both conditions. A modest but constant over-representation of Pro-allelotypes was found in all groups in comparison to the control group.

CONCLUSION:

Searching for p53 polymorphism in a clinical setting does not seem to support secondary prevention procedures, at least for women in this area.

PMID:
15140517
DOI:
10.1016/j.ejogrb.2003.10.021
[Indexed for MEDLINE]

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