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J Med Chem. 2004 May 20;47(11):2833-8.

1-alkyl-4-acylpiperazines as a new class of imidazole-free histamine H(3) receptor antagonists.

Author information

1
Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Malov, Denmark. flo@novonordisk.com

Abstract

With the aim of identifying structurally novel, centrally acting histamine H(3) antagonists, arrays of monoacyldiamines were screened. This led to the discovery of a series of 1-alkyl-4-acylpiperazines which were potent antagonists at the human histamine H(3) receptor. The most potent amides had antagonist potencies in the subnanomolar range.

PMID:
15139761
DOI:
10.1021/jm031028z
[Indexed for MEDLINE]

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