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Dig Dis Sci. 2004 Mar;49(3):353-60.

Are idiopathic and Chagasic achalasia two different diseases?

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Department of Surgical Gastroenterology, Esophagus and Stomach Division, Escola Paulista de Medicina, UNIFESP, São Paulo, Brazil.


Although Chagas' disease esophagopaty and idiopathic (primary) achalasia share several similarities, however, some differences between the two diseases have been noticed. To evaluate if treatment options and their results can be accepted universally, the authors review characteristics of both diseases in the international and Latin American literature. Neuronal denervation, sensitivity to gastrin, patient age, duration of symptoms, lower esophageal sphincter pressure, incidence of vigorous achalasia, and cancer risk are considered points of discrepancy between the maladies. Data with a high level of evidence base are scarce; however, differences between the diseases seem to exist, despite the fact that no influence on response to treatment was noticed.

[Indexed for MEDLINE]

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