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Clin Diagn Lab Immunol. 2004 May;11(3):625-6.

Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients.

Author information

1
Laboratoire d'Immunologie, de Vaccinologie et de Génétique Moléculaire, Institut Pasteur de Tunis, 13, Place Pasteur, 1002 Tunis, Tunisia.

Abstract

Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacteria. Herein, we report that the frequency of a human TLR2 Arg677Trp polymorphism (C2029T nucleotide substitution) in tuberculosis patients in Tunisia is significantly higher than in healthy controls (P < 0.0001). This finding suggests that this polymorphism could be a risk factor for tuberculosis.

PMID:
15138193
PMCID:
PMC404573
DOI:
10.1128/CDLI.11.3.625-626.2004
[Indexed for MEDLINE]
Free PMC Article

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