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Clin Diagn Lab Immunol. 2004 May;11(3):621-4.

Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation.

Author information

1
Department of Immunology and Molecular Biology, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011, USA. teresa.krakauer@det.amedd.army.mil

Abstract

Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). A pan-caspase inhibitor suppressed SE-stimulated T-cell proliferation and the production of cytokines and chemokines by human peripheral blood mononuclear cells. These data suggest that caspase inhibitors may represent a novel therapeutic modality for treating SE-induced toxic shock.

PMID:
15138192
PMCID:
PMC404582
DOI:
10.1128/CDLI.11.3.621-624.2004
[Indexed for MEDLINE]
Free PMC Article

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