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Chest. 2004 May;125(5):1726-34.

The effect of inhaled tiotropium bromide on lung mucociliary clearance in patients with COPD.

Author information

1
Department of Medical Physics, Royal Free Hampstead NHS Trust and Royal Free and University College Medical School, London, UK. amer.alhasani@royalfree.nhs.uk

Abstract

STUDY OBJECTIVE:

To assess the effects of tiotropium on lung mucociliary clearance in COPD.

DESIGN:

Randomized, double-blind, placebo-controlled, parallel-group study.

SETTING:

Outpatients of an urban-area university teaching hospital.

PATIENTS:

Thirty-four patients with COPD aged 40 to 75 years classified equally into two groups.

INTERVENTION:

Single (18 microg) daily dose of tiotropium inhalation capsules or of placebo for 21 days.

METHODS:

Six-hour tracheobronchial clearance of inhaled 99mTc-labeled polystyrene particles using a 48-h retention measurement to determine the "nontracheobronchial" deposition fraction.

RESULTS:

Test radioaerosol penetration into the lungs increased significantly (p < 0.003) as did FEV1 (p < 0.006) in the tiotropium-treated patients, but measured mucociliary clearance was not significantly changed despite the increased pathway length for clearance (mean +/- SE area under the tracheobronchial retention curve changed from 442 +/- 22 to 453 +/- 20%/h). Smaller (nonsignificant) decreases of radioaerosol penetration and FEV1 occurred in the placebo group together with a small (nonsignificant) decrease in the area under the retention curve.

CONCLUSION:

Twenty-one days of inhaled tiotropium, 18 microg/d, as a dry powder does not retard mucus clearance from the lungs.

PMID:
15136383
DOI:
10.1378/chest.125.5.1726
[Indexed for MEDLINE]

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