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Fertil Steril. 2004 May;81(5):1296-301.

Parental karyotype and subsequent live births in recurrent miscarriage.

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  • 1Sheba Medical Center, Tel Hashomer, Israel. carp@netvision.net.il

Abstract

OBJECTIVE:

To compare the subsequent live birth rate in recurrently miscarrying women with and without parental balanced chromosomal aberrations.

DESIGN:

Retrospective comparative cohort study.

SETTING:

Tertiary referral unit in a university hospital.

PATIENT(S):

Nine hundred sixteen patients with 3-16 miscarriages before 20 weeks: 99 patients with and 817 patients without chromosomal aberrations.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Outcome of the subsequent pregnancy in terms of live births or repeat miscarriage.

RESULT(S):

Of the 916 patients, 661 subsequently conceived, 73 (73.7%) with parental chromosomal aberrations and 588 (71.9%) without aberrations. In patients with and without chromosomal aberrations, 33 of 73 pregnancies (45.2%) and 325 of 588 pregnancies (55.3%), respectively, resulted in live births. The difference is not statistically significant. There was a similar prevalence of aberrations in primary, secondary, and tertiary aborters. The prevalence of aberrations was not related to the number of previous miscarriages. Translocations, inversions, and mosaicism were followed by a similar live birth rate.

CONCLUSION(S):

Patients with parental chromosomal rearrangements do not have a significantly lower live birth rate than patients without aberrations. Parental karyotyping might not be a good predictor of the outcome of subsequent pregnancies.

[PubMed - indexed for MEDLINE]
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