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J Mol Biol. 2004 May 28;339(2):327-35.

Molecular evolution of a microRNA cluster.

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Lehrstuhl für Bioinformatik am Institut für Informatik und Interdisziplinäres, Zentrum für Bioinformatik, Universität Leipzig, Germany.


Many of the known microRNAs are encoded in polycistronic transcripts. Here, we reconstruct the evolutionary history of the mir17 microRNA clusters which consist of miR-17, miR-18, miR-19a, miR-19b, miR-20, miR-25, miR-92, miR-93, miR-106a, and miR-106b. The history of this cluster is governed by an initial phase of local (tandem) duplications, a series of duplications of entire clusters and subsequent loss of individual microRNAs from the resulting paralogous clusters. The complex history of the mir17 microRNA family appears to be closely linked to the early evolution of the vertebrate lineage.

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