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Neurosci Lett. 2004 May 6;361(1-3):176-9.

A role for substance P in arthritis?

Author information

1
Centre for Cardiovascular Biology and Medicine, King's College, New Hunt's House, Guy's Campus, London SE1 1UL, UK.

Abstract

Substance P is a neuropeptide that is released from sensory nerves and which has a number of pro-inflammatory effects. In this article, we review the evidence for a role of substance P in arthritis, both in experimental animal models and rheumatoid arthritis patients. Substance P expression is altered in the joint and dorsal horn of arthritic animals, exogenous substance P and neurokinin 1 (NK(1)) receptor antagonists modulate responses in the joint, and there is some evidence for a role of substance P in human joint disease. However, the therapeutic potential of NK(1) receptor antagonists in the treatment of rheumatoid arthritis remains controversial.

PMID:
15135922
DOI:
10.1016/j.neulet.2003.12.020
[Indexed for MEDLINE]

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