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Curr Opin Immunol. 2004 Jun;16(3):360-6.

Notch signaling in lymphocyte development and function.

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Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.


Over the past few years, the crucial role of Notch signaling in multiple stages of T-cell development has become apparent. Recent studies have helped to define more precisely the functions and components of the Notch signaling pathway in T-cell development, including during the T versus B fate decision and in early CD4(-)CD8(-)double-negative thymocytes. In addition, new evidence points to a requirement for Notch2 in the development of marginal zone B cells. Finally, recent studies have provided our first glimpse into the complex and paradoxical roles of Notch signaling in the activation and differentiation of mature T cells.

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