Format

Send to

Choose Destination
Curr Opin Immunol. 2004 Jun;16(3):360-6.

Notch signaling in lymphocyte development and function.

Author information

1
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA. erobey@uclink.berkeley.edu

Abstract

Over the past few years, the crucial role of Notch signaling in multiple stages of T-cell development has become apparent. Recent studies have helped to define more precisely the functions and components of the Notch signaling pathway in T-cell development, including during the T versus B fate decision and in early CD4(-)CD8(-)double-negative thymocytes. In addition, new evidence points to a requirement for Notch2 in the development of marginal zone B cells. Finally, recent studies have provided our first glimpse into the complex and paradoxical roles of Notch signaling in the activation and differentiation of mature T cells.

PMID:
15134786
DOI:
10.1016/j.coi.2004.03.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center