Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Struct Mol Biol. 2004 Jun;11(6):574-5. Epub 2004 May 9.

The stalk region of dynamin drives the constriction of dynamin tubes.

Author information

1
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA.

Abstract

The GTPase dynamin is essential for numerous vesiculation events including clathrin-mediated endocytosis. Upon GTP hydrolysis, dynamin constricts a lipid bilayer. Previously, a three-dimensional structure of mutant dynamin in the constricted state was determined by helical reconstruction methods. We solved the nonconstricted state by a single-particle approach and show that the stalk region of dynamin undergoes a large conformational change that drives tube constriction.

PMID:
15133500
DOI:
10.1038/nsmb762
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center