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Biomacromolecules. 2004 May-Jun;5(3):846-51.

Quantification of the effects of chain length and concentration on the thermal behavior of elastin-like polypeptides.

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Department of Biomedical Engineering, Box 90281, Duke University, Durham, North Carolina 27708-0281, USA.


At a specific temperature, elastin-like polypeptides (ELPs) undergo a sharp solubility transition that can be exploited in a variety of applications in biotechnology and medicine. The temperature of the transition varies with ELP sequence, molecular weight, and concentration. We present a single equation of three parameters that quantitatively predicts the transition temperature as a function of ELP length and concentration for an ELP of a fixed composition. This model should be useful both for the design of new ELP sequences that exhibit a desired transition temperature and for the selection of variables to trigger the phase transition of an ELP for a given application.

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