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Genome Biol. 2004;5(5):R34. Epub 2004 Apr 27.

Orthologous gene-expression profiling in multi-species models: search for candidate genes.

Author information

1
Center for Translational Respiratory Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, East Monument Street, Baltimore, MD 21287, USA.

Abstract

Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.

PMID:
15128448
PMCID:
PMC416470
DOI:
10.1186/gb-2004-5-5-r34
[Indexed for MEDLINE]
Free PMC Article

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