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Am J Ophthalmol. 2004 May;137(5):951-3.

SANDO: another presentation of mitochondrial disease.

Author information

1
Department of Neurology, University of Florida College of Medicine, Box 100284, Gainesville, FL 32610, USA.

Abstract

PURPOSE:

To describe a unique mitochondrial syndrome that may present with the combination of ocular manifestations, sensory symptoms, and speech dysfunction.

DESIGN:

Case report.

METHODS:

Case report and review of the literature.

RESULTS:

A 43-year-old man presented with a Sensory Ataxic Neuropathy, Dysarthria, and Ophthalmoparesis (SANDO). Nerve conduction studies showed a sensory ganglionopathy. Skeletal muscle biopsy revealed ragged red fibers, and polymerase chain reaction analysis of the tissue demonstrated multiple mitochondrial DNA deletions.

CONCLUSION:

Mitochondrial disease should be considered in cases of external ophthalmoplegia, especially if a sensory ganglionopathy and dysarthria are present.

PMID:
15126171
DOI:
10.1016/j.ajo.2003.10.046
[Indexed for MEDLINE]

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