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Bioorg Med Chem Lett. 2004 Jun 7;14(11):2847-51.

PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues.

Author information

1
Department of Medicine, Monash University, Box Hill Hospital, Box Hill 3128, Australia.

Abstract

Synthetic 2-morpholinochromones, including the known PI3-kinase inhibitor LY294002, have been evaluated in vitro as inhibitors of isolated human platelet phosphodiesterases. Inhibition of the cAMP-phosphodiesterases, PDE2 and PDE3 by LY294002 is reported for the first time. Preliminary screening across a range of 2-morpholinochromones has revealed structural features for optimised PDE2 inhibition.

PMID:
15125945
DOI:
10.1016/j.bmcl.2004.03.043
[Indexed for MEDLINE]

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