Format

Send to

Choose Destination
See comment in PubMed Commons below
Growth Horm IGF Res. 2004 Jun;14(3):195-9.

Genetic strategies for elucidating insulin-like growth factor action in bone.

Author information

1
Division of Endocrinology, University of Cincinnati and Division of Pediatric Endocrinology, Cincinnati Children's Hospital, Cincinnati, OH, USA. tclemens@path.uab.edu

Abstract

While it is universally accepted that IGFs serve important roles in bone acquisition and maintenance, the precise cellular targets and molecular mechanisms responsible for their actions have remained poorly understood. Recent advances in genetic techniques to manipulate the mouse genome have enabled the examination of individual components of the IGF system in vivo. Observations in these mouse models have provided new insights into the skeletal actions of IGF which have significant implications for understanding IGF action in human bone.

PMID:
15125880
DOI:
10.1016/j.ghir.2003.12.008
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center