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J Clin Invest. 2004 May;113(9):1255-7.

Dysbindin-1 and schizophrenia: from genetics to neuropathology.

Author information

1
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom. owenmj@cf.ac.uk

Abstract

The gene encoding dysbindin-1 has recently been implicated in susceptibility to schizophrenia. In this issue of the JCI, Talbot et al. show that, contrary to expectations, dysbindin-1 is located presynaptically in glutamatergic neurons and is reduced at these locations in schizophrenia. Further studies of dysbindin-1 and the proteins with which it interacts can be expected to throw light on the pathogenesis of schizophrenia.

PMID:
15124015
PMCID:
PMC398436
DOI:
10.1172/JCI21470
[Indexed for MEDLINE]
Free PMC Article

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