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J Clin Invest. 2004 May;113(9):1251-3.

Anemia of inflammation: the cytokine-hepcidin link.

Author information

1
Children's Hospital, Howard Hughes Medical Institute, Harvard Medical School, and Dana-Farber Cancer Institute, Boston, Massachusetts 02115-5737, USA. nandrews@enders.tch.harvard.edu

Abstract

The anemia of inflammation, commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders, is a well-known clinical entity. Until recently, we understood little about its pathogenesis. It now appears that the inflammatory cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be responsible for most or all of the features of this disorder.

PMID:
15124013
PMCID:
PMC398435
DOI:
10.1172/JCI21441
[Indexed for MEDLINE]
Free PMC Article

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