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Chem Biol. 2004 Feb;11(2):149-51.

RNA: primed for packing?

Author information

1
Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720, USA.

Abstract

How does RNA's seemingly subtle 2'-hydroxyl group contribute to its diverse biological functions? Using quantitative structure-activity relationship (QSAR) analysis, Piccirilli and colleagues find that the 2'-OH fosters van der Waals and hydrophobic interactions that play underappreciated roles in RNA structure and molecular recognition.

PMID:
15123272
DOI:
10.1016/j.chembiol.2004.02.007
[Indexed for MEDLINE]
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