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Obstet Gynecol. 2004 May;103(5 Pt 2):1118-20.

Management of Eisenmenger syndrome in pregnancy with sildenafil and L-arginine.

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1
Pontificia Universidad Católica de Chile, Santiago, Chile.

Abstract

BACKGROUND:

Eisenmenger syndrome in pregnancy may be a life-threatening disease despite recent additions to the treatment options.

CASE:

We present a woman with severe pulmonary hypertension due to Eisenmenger syndrome treated during pregnancy and delivery and postpartum with L-arginine and sildenafil to enhance the nitric oxide pathway. This combination was associated with significant improvement in the mother's clinical and hemodynamic condition and fetal well-being.

CONCLUSION:

The concomitant use of sildenafil and L-arginine for the management of pulmonary hypertension in pregnancy, combined with multidisciplinary care, permitted a good outcome for the mother and her infant.

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