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Vaccine. 2004 May 7;22(15-16):2064-70.

Control without separate controls: evaluation of vaccine safety using case-only methods.

Author information

1
Department of Statistics, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK. c.p.farrington@open.ac.uk

Abstract

Epidemiological methods involving only cases are reviewed in the context of vaccine safety studies. These methods include some ecological methods, case-coverage methods, case-crossover and self-controlled case series methods. The properties of the methods are described using examples from the literature. It is argued that such methods, and in particular the self-controlled case series method, are powerful epidemiologic tools meriting the same attention as more traditional cohort and case-control methods.

PMID:
15121324
DOI:
10.1016/j.vaccine.2004.01.017
[Indexed for MEDLINE]

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