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Trends Mol Med. 2004 May;10(5):201-4.

Ezrin, a key component in tumor metastasis.

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Laboratory of Population Genetics, CCR/NCI/NIH, 41 Library Drive, Bethesda, MD 20892-5060, USA.


Identification of the key regulatory molecules in metastasis is crucial for understanding tumor dissemination and for the development of novel interventions. The recent identification of ezrin as a necessary component in the metastasis of osteosarcoma and rhabdomyosarcoma is, therefore, an important advance. Ezrin has been implicated in many roles, for example, as a conduit for signals between metastasis-associated cell-surface molecules and signal transduction components. This suggests that ezrin and, potentially, other members of the ERM (ezrin-radixin-moesin) family have key roles in the coordination of signals and cellular complexes that are required for the successful metastasis of these and other malignancies.

[Indexed for MEDLINE]

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