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Exp Cell Res. 2004 May 15;296(1):21-7.

Assembly of kinetochores in vertebrate cells.

Author information

1
PRESTO, the Japan Science and Technology Agency (JST), National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411-8540, Japan. tfukagawa@lab.nig.ac.jp

Abstract

The centromere is a specialized region of each chromosome that is essential for faithful chromosome segregation during mitosis and meiosis in eukaryotic cells. Centromeres are the site at which kinetochores are formed. The kinetochore is responsible for microtubule binding and chromosome movement. In this review, I will focus on recent advances in our understanding of centromere DNAs as sites for kinetochore assembly and the mechanism underlying kinetochore assembly in vertebrate cells.

PMID:
15120989
DOI:
10.1016/j.yexcr.2004.03.004
[Indexed for MEDLINE]

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