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Ann Clin Biochem. 2004 May;41(Pt 3):233-6.

Dimercaptosuccinic acid loading test for assessing mercury burden in healthy individuals.

Author information

1
Department of Clinical Biochemistry, Belfast City Hospital, Belfast BT9 7AD, Northern Ireland, UK. pooler.archbold@bll.n-i.nhs.uk

Abstract

BACKGROUND:

Oral chelation tests have been used to try to define mercury toxicity in individuals with dental amalgams, who are suffering from a variety of non-specific symptoms.

METHODS:

Self-reported healthy individuals volunteered to undergo an oral chelation test using dimercaptosuccinic acid (DMSA) at a dose of 30 mg/kg body weight. Urinary mercury : creatinine ratios were measured pre-dose and 3 h post-dose.

RESULTS:

Urinary mercury : creatinine ratios were similar to levels previously reported in individuals with symptoms that could have been attributed to mercury toxicity. One volunteer suffered a serious reaction to DMSA.

CONCLUSION:

The oral chelation test using DMSA may lead to misleading diagnostic advice regarding potential mercury toxicity and can be associated with serious side effects.

PMID:
15117439
DOI:
10.1258/000456304323019622
[Indexed for MEDLINE]
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