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Nat Neurosci. 2004 May;7(5):429-33.

Neurogenomics: at the intersection of neurobiology and genome sciences.

Author information

1
Allen Institute for Brain Science, 551 N. 34th Street, Seattle, Washington 98103, USA. markbo@alleninstitute.org
2
Allen Institute for Brain Science, 551 N. 34th Street, Seattle, Washington 98103, USA.

Abstract

Neurogenomics is the study of how the genome as a whole contributes to the evolution, development, structure and function of the nervous system. It includes investigations of how genome products (transcriptomes and proteomes) vary in time and space. Neurogenomics differs markedly from the application of genome sciences to other systems, particularly in the spatial category, because anatomy and connectivity are paramount to our understanding of function in the nervous system. We focus here on some of the influences of genomics and its associated technologies on neuroscience. We discuss comparative genomics, gene expression atlases of the brain, network genetics and applications to behavioral phenotypes, and consider the culture, organization and funding of genome-scale projects.

PMID:
15114353
DOI:
10.1038/nn1232
[Indexed for MEDLINE]
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