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Nat Struct Mol Biol. 2004 May;11(5):394-403.

Structure and mechanism of the RNA polymerase II transcription machinery.

Author information

1
Fred Hutchinson Cancer Research Center and Howard Hughes Medical Institute, 1100 Fairview Ave N., A1-162, Seattle, Washington 98109, USA. shahn@fhcrc.org

Abstract

Advances in structure determination of the bacterial and eukaryotic transcription machinery have led to a marked increase in the understanding of the mechanism of transcription. Models for the specific assembly of the RNA polymerase II transcription machinery at a promoter, conformational changes that occur during initiation of transcription, and the mechanism of initiation are discussed in light of recent developments.

PMID:
15114340
PMCID:
PMC1189732
DOI:
10.1038/nsmb763
[Indexed for MEDLINE]
Free PMC Article
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