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J Virol. 2004 May;78(10):5520-2.

Effects of antibody on viral kinetics in simian/human immunodeficiency virus infection: implications for vaccination.

Author information

1
Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, New South Wales 2052, Australia.

Abstract

Passive antibody treatment of macaques prior to simian/human immunodeficiency virus infection produces "sterilizing immunity" in some animals and long-term reductions in viral loads in others. Analysis of viral kinetics suggests that antibody mediates sterilizing immunity by its effects on the initial viral inoculum. By contrast, reduction in peak viral load later in infection prevents CD4 depletion and contributes to long-term viral control.

PMID:
15113932
PMCID:
PMC400367
[Indexed for MEDLINE]
Free PMC Article

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