Format

Send to

Choose Destination
Spinal Cord. 2004 Jul;42(7):417-9.

Magnetic brain stimulation can improve clinical outcome in incomplete spinal cord injured patients.

Author information

1
Division of Neuroscience & Psychological Medicine, Faculty of Medicine, Imperial College, Charing Cross Hospital, London, UK.

Abstract

STUDY DESIGN:

Preliminary longitudinal clinical trial.

OBJECTIVES:

To test the efficacy of repetitive transcranial magnetic stimulation (rTMS) in modulating corticospinal inhibition and improving recovery in stable incomplete spinal cord injury (iSCI).

SETTING:

National Spinal Injuries Centre, Stoke Mandeville Hospital, Bucks, UK and Division of Neuroscience, Imperial College Faculty of Medicine, Charing Cross Hospital, London, UK.

METHODS:

Four stable iSCI patients were treated with rTMS over the occipital cortex (sham treatment) and then over the motor cortex (real treatment). Patients were assessed using electrophysiological, clinical and functional measures before treatment, during sham treatment, during the therapeutic treatment and during a 3-week follow-up period.

RESULTS:

Cortical inhibition was reduced during the treatment week. Perceptual threshold to electrical stimulation of the skin, ASIA clinical measures of motor and sensory function and time to complete a peg-board improved and remained improved into the follow-up period.

CONCLUSION:

In this preliminary trial, rTMS has been shown to alter cortical inhibition in iSCI and improve the clinical and functional outcome.

SPONSORSHIP:

This work was supported by the International Spinal Research Trust.

PMID:
15111994
DOI:
10.1038/sj.sc.3101613
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center