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Ann Oncol. 2004 May;15(5):770-4.

Gemcitabine concurrent with continuous infusional 5-fluorouracil in advanced biliary cancers: a review of the Princess Margaret Hospital experience.

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1
Departments of Hematology and Medical Oncology, Princess Margaret Hospital/University Health Network, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9. jennifer.knox@uhn.on.ca

Abstract

BACKGROUND:

Unresectable biliary tract cancer has a very poor prognosis. A combination of weekly gemcitabine plus continuous infusional 5-fluorouracil (5-FU) (GEM/CVI 5-FU) was evaluated as therapy for this cancer.

PATIENTS AND METHODS:

The charts of 27 patients with advanced biliary tract adenocarcinoma treated with GEM/CVI 5-FU at the Princess Margaret Hospital were evaluated for response, survival and toxicity. The treatment consisted of a 30-min infusion of gemcitabine at 900 mg/m(2) on days 1, 8 and 15 of a 28-day cycle plus 5-FU given via a peripherally inserted central line at 200 mg/m(2)/day continuously for 21 days, every 28 days.

RESULTS:

Objective responses were observed in nine patients (33%; 95% confidence interval 17% to 54%). An additional eight patients (30%) achieved stable disease for a median of 4 months (range 2.3-11). Median time to progression and overall survival were 3.7 and 5.3 months, respectively. Direct chemotherapy-related toxicity was mild, with only 11% grade > or =3 myelosuppression. Central venous catheter complications were common (26%). There were no treatment-related deaths.

CONCLUSIONS:

This study shows that GEM/CVI 5-FU is active and well tolerated in advanced and metastatic biliary tract cancers.

PMID:
15111345
[Indexed for MEDLINE]
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