Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities

Yurngdong Jahng; Long-Xuan Zhao; Yoon-Soo Moon; Arjun Basnet; Eun-kyung Kim; Hyeun Wook Chang; Hye Kyung Ju; Tae Cheon Jeong; Eung-Seok Lee

doi:10.1016/j.bmcl.2004.02.099

Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities

Bioorg Med Chem Lett. 2004 May 17;14(10):2559-62. doi: 10.1016/j.bmcl.2004.02.099.

Authors

Yurngdong Jahng¹, Long-Xuan Zhao, Yoon-Soo Moon, Arjun Basnet, Eun-kyung Kim, Hyeun Wook Chang, Hye Kyung Ju, Tae Cheon Jeong, Eung-Seok Lee

Affiliation

¹ College of Pharmacy, Yeungnam University, Kyongsan 712-749, South Korea.

PMID: 15109651
DOI: 10.1016/j.bmcl.2004.02.099

Abstract

For the development of safer anti-inflammatory agents, simple aromatic compounds containing propenone moiety were prepared and evaluated for their dual COX/5-LOX inhibitory activities. Among the 17 prepared compounds, most of the compounds exhibited considerable COX/5-LOX inhibitory activities. Especially compound C(15) showed the most significant dual COX/5-LOX inhibitory activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Bone Marrow Cells / enzymology
Cyclooxygenase Inhibitors / chemical synthesis*
Cyclooxygenase Inhibitors / pharmacology
Drug Design
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / pharmacology
Hydrocarbons, Aromatic / chemical synthesis
Hydrocarbons, Aromatic / pharmacology*
Inhibitory Concentration 50
Ketones / chemical synthesis
Ketones / pharmacology
Lipoxygenase Inhibitors*
Male
Mice
Mice, Inbred BALB C
Structure-Activity Relationship

Substances

Anti-Inflammatory Agents, Non-Steroidal
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Hydrocarbons, Aromatic
Ketones
Lipoxygenase Inhibitors