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Emerg Infect Dis. 2004 Mar;10(3):514-7.

Antibiotic selection pressure and resistance in Streptococcus pneumoniae and Streptococcus pyogenes.

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1
Emory University School of Medicine, Atlanta, Georgia, USA.

Abstract

We correlated outpatient antibiotic use with prevalence of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP), macrolide-resistant S. pneumoniae (MRSP), and macrolide-resistant S. pyogenes (MRGAS) in 20 countries. Total antibiotic use was correlated with PNSP (r = 0.75; p < 0.001), as was macrolide use with MRSP (r = 0.88; p < 0.001) and MRGAS (r = 0.71; p = 0.004). Streptococcal resistance is directly associated with antibiotic selection pressure on a national level.

PMID:
15109426
PMCID:
PMC3322805
DOI:
10.3201/eid1003.030252
[Indexed for MEDLINE]
Free PMC Article
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