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Curr Opin Genet Dev. 2004 Feb;14(1):86-91.

Genes that drive invasion and migration in Drosophila.

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Department of Biological Chemistry, Johns Hopkins Medical Institute, Wood Basic Science Building 413, 725 N Wolfe Street, Baltimore, MD 21205, USA.


Successful cell migration depends on the careful regulation of the timing of movement, the guidance of motile cells, and cytoskeletal and adhesive changes within the cells. This review focuses on genes that act cell-autonomously to promote these aspects of cell migration in Drosophila. We discuss recent advances in understanding the migration of the ovarian border cells, embryonic blood cells, primordial germ cells, somatic gonadal precursors, and tracheal cells. Comparison of genes that regulate these processes to those that promote tumorigenesis and metastasis in mammals demonstrates that studies in fruit flies are uncovering new genes highly relevant to cancer biology.

[Indexed for MEDLINE]

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