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Curr Opin Genet Dev. 2004 Feb;14(1):65-70.

Ski and SnoN: negative regulators of TGF-beta signaling.

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Life Sciences Division, Lawrence Berkeley National Laboratory and Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, 237 Hildebrand Hall, Mail code 3206, Berkeley, CA 94720-3206, USA.


Ski and SnoN are unique proto-oncoproteins in that they can induce both oncogenic transformation and terminal muscle differentiation when expressed at high levels. Recent studies using in vitro and in vivo approaches have begun to unravel the complex roles of Ski and SnoN in tumorigenesis and embryonic development. The identification of Ski and SnoN as important negative regulators of signal transduction by the transforming growth factor-beta superfamily of cytokines provides a valuable molecular basis for the complex functions of Ski and SnoN.

[Indexed for MEDLINE]

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