Format

Send to

Choose Destination
Curr Opin Genet Dev. 2004 Feb;14(1):22-8.

Those dam-aged telomeres!

Author information

1
Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada. leah@uhnres.utoronto.ca

Abstract

Telomere integrity plays a crucial role in the capacity for continuous cell proliferation. In some circumstances, shortened telomeres contribute to cell arrest or death, but in others, shortened telomeres may actually enhance the incidence and spectrum of tumors. Resolution of this apparent paradox requires a more detailed understanding of a non-functional telomere. Recent evidence reveals that critically shortened or uncapped telomeres share molecular hallmarks of damaged DNA. It is likely that the cellular response to this DNA damage, influenced by the nature of the damage itself, affects the outcome of loss of telomere function.

PMID:
15108801
DOI:
10.1016/j.gde.2003.12.007
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center