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Biochem Pharmacol. 1992 Aug 4;44(3):409-12.

The sensitivity of human tumour cells to quinone bioreductive drugs: what role for DT-diaphorase?

Author information

1
MRC Radiobiology Unit, Chilton, Didcot.

Abstract

15 human tumour cell lines (lung, breast and colon) have been evaluated for their sensitivity to the quinone based anti-cancer drugs Mitomycin C, Porfiromycin, and EO9 (3-hydroxymethyl-5-aziridinyl-1-methyl-2-(IH-indole-4,7-dione)prop-beta- en-alpha-ol). Sensitivity has been compared with the intra-cellular levels of DT-diaphorase, an enzyme thought to be important in the reductive activation of these quinones. No correlation exists between levels of DT-diaphorase and sensitivity to Mitomycin C or Porfiromycin. However, for EO9 those cell lines showing highest levels of DT-diaphorase activity tend to be the most sensitive.

PMID:
1510692
DOI:
10.1016/0006-2952(92)90429-m
[Indexed for MEDLINE]

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