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Biochem Biophys Res Commun. 1992 Aug 14;186(3):1487-95.

Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos.

Author information

1
Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.

Abstract

We have previously demonstrated that activin, a member of the TGF-beta family, has a potent mesoderm-inducing activity in Xenopus embryos. In the course of screening for activin-related genes from Xenopus, we have cloned cDNAs for Xenopus homologue of BMP-2, -4 and -7. Northern blot analysis revealed that these BMP genes are maternally encoded and differentially regulated after fertilization. Alkaline phosphatase-inducing assay using the recombinant BMP proteins has shown that at least BMP-2 and -4 have similar activity to mammalian counterparts.

PMID:
1510675
DOI:
10.1016/s0006-291x(05)81574-8
[Indexed for MEDLINE]

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