Format

Send to

Choose Destination
Trends Cell Biol. 2004 Feb;14(2):55-7.

The talin wags the dog: new insights into integrin activation.

Author information

1
Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA.

Abstract

Integrin transmembrane receptors have a unique property that distinguishes them from other signaling receptors. Their affinity for ligands can be modulated from the inside out in response to intracellular signals generated by non-integrin receptors. Recent findings provide novel mechanistic insights into this process by demonstrating that talin, a protein that links integrins to actin, is necessary for the inside-out activation of integrins.

PMID:
15106607
DOI:
10.1016/j.tcb.2003.12.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center