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Antimicrob Agents Chemother. 2004 May;48(5):1908-11.

Novel inhalational murine model of invasive pulmonary aspergillosis.

Author information

1
St. John's Cardiovascular Research Center, Division of Infectious Diseases, Department of Medicine, Harbor-UCLA Research and Education Institute, Torrance, California 90502, USA.

Abstract

We developed a novel model of invasive aspergillosis (IA) that recapitulates human disease. Mice were immunosuppressed with cyclophosphamide and cortisone acetate and then infected in an aerosol chamber. This procedure reproducibly delivered 1 x 10(3) to 3 x 10(3) conidia to the lungs. Lethal pulmonary IA developed over 2 weeks and was prevented by amphotericin B.

PMID:
15105158
PMCID:
PMC400587
[Indexed for MEDLINE]
Free PMC Article

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