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Antimicrob Agents Chemother. 2004 May;48(5):1889-91.

Differential expression levels of MRP1, MRP4, and MRP5 in response to human immunodeficiency virus infection in human macrophages.

Author information

1
CEA, Service de Neurovirologie, Université Paris XI, CRSSA, EPHE, IPS, Fontenay-aux-Roses, France.

Abstract

Multidrug resistance proteins (MRPs) have been reported to be involved in the efflux of some anti-human immunodeficiency virus (HIV) drugs. We show here that MRP1, MRP4, and MRP5 are expressed at the mRNA level in human monocyte-derived macrophages. HIV infection caused increased transcription of these MRPs; however, temporal differences in stimulation are reported.

PMID:
15105153
PMCID:
PMC400539
DOI:
10.1128/aac.48.5.1889-1891.2004
[Indexed for MEDLINE]
Free PMC Article

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