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Ann Allergy Asthma Immunol. 2004 Apr;92(4):464-8.

Anaphylaxis: a 7-year follow-up survey of 46 children.

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1
Allergy and Clinical Immunology Unit, III Pediatric Clinic, University of Florence, Italy.

Abstract

BACKGROUND:

Little is known about the frequency of and the features associated with recurrent anaphylaxis in pediatric populations. During 1994 to 1996, we enrolled 76 children affected by anaphylaxis in a prospective study to analyze their clinical and allergic features.

OBJECTIVE:

To undertake a follow-up study of these children to ascertain how many experienced a recurrence of anaphylaxis.

METHODS:

After a mean interval of 7 years, a pediatric allergist conducted a telephone interview of patients who had been enrolled in our 1994-1996 study.

RESULTS:

A telephone interview was successfully completed in 46 (61%) of the 76 patients who had been enrolled in our 1994-1996 study. Of these 46 patients, 14 (30%) had experienced a recurrence of anaphylaxis. Children with atopic dermatitis either during 1994 to 1996 (64% vs 34%; P = .04) or at the time of the current study (43% vs 16%; P = .03) and those with urticaria-angioedema at the time of the current study (93% vs 31%; P = .0002) were found to be at a significantly higher risk for recurrent anaphylaxis. Furthermore, those children who were sensitive to at least 1 food allergen during 1994 to 1996 were more likely to have experienced a recurrence of anaphylaxis (93% vs 56%; P < .04).

CONCLUSIONS:

This study suggests that patients may have a greater risk of recurrence of anaphylaxis if they have atopic dermatitis, urticaria-angioedema, or at least 1 positive result of skin prick tests to food allergens.

PMID:
15104200
DOI:
10.1016/S1081-1206(10)61784-X
[Indexed for MEDLINE]
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