Format

Send to

Choose Destination
See comment in PubMed Commons below
Trends Neurosci. 2004 Feb;27(2):77-83.

On the electrical function of dendritic spines.

Author information

1
Department of Biological Sciences, Columbia University, 1002 Fairchild, New York, NY 10032, USA. dt133@columbia.edu

Abstract

Dendritic spines mediate most excitatory inputs in the brain, yet their function is still unclear. Imaging experiments have demonstrated their role in biochemical compartmentalization at individual synapses, yet theoretical studies have suggested that they could serve an electrical function in transforming synaptic inputs and transmitting dendritic spikes. Recent data indicate that spines possess voltage-dependent conductances and that these channels can be spine-specific. Although direct experimental investigations of the electrical properties of spines have not yet taken place, spines could play a significant electrical role, greatly influencing dendritic integration and the function of neural circuits.

PMID:
15102486
DOI:
10.1016/j.tins.2003.11.008
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center