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Trends Immunol. 2004 Feb;25(2):98-104.

Jump-starting the immune system: prime-boosting comes of age.

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Trudeau Institute, 154 Algonquin Ave., Saranac Lake, NY 12983, USA.


A major challenge for immunologists has been the development of vaccines designed to emphasize cellular immune responses. One particularly promising approach is the prime-boost strategy, which has been shown to generate high levels of T-cell memory in animal models. Recently, several papers have highlighted the power of prime-boost strategies in eliciting protective cellular immunity to a variety of pathogens and have demonstrated efficacy in humans. Coupled with recent advances in our understanding of the mechanisms underlying the generation, maintenance and recall of T-cell memory, the field is poised to make tremendous progress. This Review discusses the impact of these recent developments on the future of prime-boost vaccine strategies.

[Indexed for MEDLINE]

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